WebMicrotubule (MT) dynamic instability is driven by GTP hydrolysis and regulated by microtubule-associated proteins, including the plus-end tracking end-binding protein … Web12 apr. 2024 · In this work, we studied the dynamics of IFs using their subunits tagged with a photoconvertible protein mEOS 3.2. We have demonstrated that the loss of gigaxonin dramatically inhibited transport of IFs along microtubules by the microtubule motor kinesin-1. This inhibition was specific for IFs, as other kinesin-1 cargoes, ...
Regulation of microtubule dynamic instability
WebThe invention provides application of an autophagy inducer serving as a microtubule stabilizing drug to the promotion of nerve regeneration. Specifically, the invention provides a method for promotingthe enation of in vitro culture central neuron and weakening the inhibiting effect on enation by myelin, or stabilizing microtubules central nervous … Web19 mei 2016 · Microtubule poisons inhibit spindle function, leading to activation of spindle assembly checkpoint (SAC) and mitotic arrest. Cell death occurring in prolonged mitosis … ian fitzwater
A theory of microtubule catastrophes and their regulation PNAS
WebMechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins [2015] Zhang, Rui; Gregory M. Alushin; Alan Brown; Eva Nogales; Microtubule (MT) dynamic instability is driven by GTP hydrolysis and regulated by microtubule-associated proteins, including the plus-end tracking end-binding protein (EB) family. WebIn this review, we describe the mechanisms that regulate microtubule dynamics and underlie dynamic instability, and discuss how dynamic instability may shape … WebMT assembly and disassembly is modulated by a complex network of intracellular factors that co-operate or antagonize each other, are highly regulated in space and … moms organic hq