Neotanshinlactone

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August undefined, 2024

WebJan 1, 2024 · Neo-tanshinlactone (NTL) a natural product is known for its specificity and selectivity towards the breast cancer cells. By NTL D-ring modification approach, 13 new analogues were synthesized (1A-1M). Among them 1J showed the best anticancer activity in MCF-7 (ER+, PR+/-, HER2-), SKBR3 (ER-, PR-, HE … WebDec 14, 2015 · The genus of Salvia is a large pool of diterpenoids with structural diversity and biological properties [1–3].Many diterpenoids with interesting bioactivities, such as tanshinone IIA, salvicine, neotanshinlactone, and salvinorin A, have been reported from this genus [4–6].Salvia yunnanensis is a traditional Chinese herb used as the surrogate …

Antitumor agents 269. Non-aromatic ring-A neotanshinlactone

WebNeo-tanshinlactone (1) was synthesized by the intramolecular coupling reaction of the precursor ester, which was prepared from the corresponding furan carboxylic acid (13) and naphthol (3), using a palladium reagent. Neo-tanshinlactone (1) is a natural heterocyclic compound, which was isolated from the rhizome of Salvia miltiorrhiza Bunge, and its … WebSep 1, 2016 · To test in vitro anti-proliferative activity of neo-tanshinlactone, two ER+ breast cancer cell lines (MCF7 and ZR-75-1), three ER- breast cancer cell lines (MDA-MB-231, … cssrc dallas texas

Neo-tanshinlactone C17H12O3 - PubChem

WebDec 1, 2010 · Natural and synthetic coumarins have been found to exhibit a variety of pharmacological activities like anti-HIV, 9 anticoagulant, 10 antibacterial, 11 antioxidant, … WebSep 1, 2016 · Breast cancer, the most frequent cancer in women, is the second leading cause of cancer-related death. Estrogens and estrogen receptors are well recognized to play predominant roles in breast cancer development and growth. Neo-tanshinlactone is a natural product isolated from Salvia miltiorrhiza and showed selective growth inhibition of … WebBreast cancer, the most frequent cancer in women, is the second leading cause of cancer-related death. Estrogens and estrogen receptors are well recognized to play predominant … cssrc dallas credit card charge

Antitumor agents. 272. Structure-activity relationships and in vivo ...

Antitumor agents 269. Non-aromatic ring-A neotanshinlactone …

WebEpothilones, a new class of cancer drugs, are also inhibitors of microtubule function and are represented by ixabepilone (28.1.89) and eribulin (28.1.90). Ixabepilone is a semisynthetic analogue of epothilone B that binds to the same site on β-tubulin as paclitaxel and may be a more potent polymerizer of tubulin. earls vip relocationWebJan 1, 2024 · Neo-tanshinlactone (NTL) a natural product is known for its specificity and selectivity towards the breast cancer cells. By NTL D-ring modification approach, 13 new … earls view fishery rules

"WebJan 1, 2024 · Worldwide 1.2 million breast cancer (BC) cases were estimated per year and that remains a common cause of mortality and morbidity in woman, despite … " - Neotanshinlactone

Neotanshinlactone

Webneotanshinlactone Medicine & Life Sciences 100%. Structure-Activity Relationship Medicine & Life Sciences 49%. Antineoplastic Agents Medicine & Life Sciences 40%. Antineoplastic Agent Chemical Compounds 37%. Breast Neoplasms Medicine & Life Sciences 26%. Heterografts Medicine & Life Sciences 25%. Webneotanshinlactone Medicine & Life Sciences 92%. Microtubule-Destabilising Agent Chemical Compounds 37%. Occurrence in Nature Chemical Compounds 32%. Colorectal Neoplasms Medicine & Life Sciences 30%. Microtubules Medicine & Life Sciences 28%. Cytoprotective Chemical Compounds 27%.

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WebNov 15, 2009 · Tetrahydroneotanshinlactone (TNT) and tetrahydronaphthalene-1-ol (TNO) derivatives were designed, synthesized, and evaluated for cytotoxic activity. The TNO … WebJun 20, 2024 · Several neo-tanshinlactone derivatives with fluorine or the trifluoromethyl group were synthesized and their antiproliferative activities were evaluated. Compared with neo-tanshinlactone, fluorinated derivatives showed a broad activity spectrum against human tumor lines. For a neo-tanshinlactone chemical skeleton, these results also …

WebJan 1, 2024 · Worldwide 1.2 million breast cancer (BC) cases were estimated per year and that remains a common cause of mortality and morbidity in woman, despite advancement in therapy and early diagnosis. 1 Various natural products are known to kill the cancer cells in vitro as well as in vivo studies. Drug discovery in the treatment of cancer was … WebOct 1, 2016 · Request PDF Neo-tanshinlactone D-Ring Modified Novel analogues Induce Apoptosis in Human Breast Cancer Cell via DNA Damage Neo-tanshinlactone (NTL) a …

WebDec 1, 2004 · Neotanshinlactone selectively inhibits the proliferation of estrogen receptor positive breast cancer cells through transcriptional down-regulation of estrogen receptor … WebIn our previous study, neo-tanshinlactone (1) showed potent and selective anti-breast cancer activity. To explore the SAR of 1, nine analogues (15−18, 24−28) were designed and …

WebMar 11, 2010 · Neo-tanshinlactone (1) and its previously reported analogues, such as 2, are potent and selective in vitro antibreast cancer agents. The synthetic pathway to 2 was optimized from seven to five steps, with a better overall yield. Structure-activity relationships studies on these compounds revealed so …

WebFour series of molecular hybrids (37 final products) of neo-tanshinlactone, a natural product extracted from Salvia miltiorrhiza Bunge, and known PD-1/PD-L1 interaction inhibitors … cssr catholicWebMar 14, 2024 · Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents earls vlogs familyWebNov 15, 2009 · Compounds 1 and 2 have been studied extensively for their antitumor effects, and display different activities and selectivities. 8 Recent studies indicated that 1 … css re01WebMar 23, 2010 · ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option. css react boxWebNov 15, 2009 · Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents Author links open overlay panel Yizhou Dong a , Qian Shi a , … earls v twin tehachapiWebJun 20, 2024 · Several neo-tanshinlactone derivatives with fluorine or the trifluoromethyl group were synthesized and their antiproliferative activities were evaluated. Compared … cssr chartWebSep 29, 2009 · Cancer is the second leading cause of death in the United States, accounting for one-quarter of all deaths. 1 Cancer incidence and resultant mortality have increased by approximately 22% since 1990, 2 and 1,400,000 new cancer cases will be diagnosed in 2009, according to estimates by the American Cancer Society. 3 Natural … css rcon in console