Tīmeklis2024. gada 21. maijs · Mechanistically, we demonstrate that Qki enhances cholesterol biosynthesis by recruiting Srebp2 and Pol II in the promoter regions of cholesterol … Tīmeklis2024. gada 21. maijs · It is proposed that Qki-Srebp2–mediated cholesterol biosynthesis is essential for maintaining the cholesterol level that protects lens from cataract development. Defective cholesterol biosynthesis in eye lens cells is often associated with cataracts; however, how genes involved in cholesterol biosynthesis …
6721 - Gene ResultSREBF2 sterol regulatory element binding ...
Tīmeklis2016. gada 1. sept. · It is found that oligodendroglial development and myelination are adversely affected in the cerebellum of qkv mice, and QKI disruption can impact the cell fate of oligod endodendrocyte precursor cells, their migration and differentiation, and ultimatelyMyelination in the Cerebellum. The selective RNA‐binding protein Quaking I … TīmeklisMechanistically, we have identified Qki as a transcriptional reg- ulator of Srebp2-mediated transcription of cholesterol biosynth- esis genes. In addition, we show that … ourplantbasedfamily.com
QKI Gene - GeneCards QKI Protein QKI Antibody
TīmeklisMechanistically, we demonstrate that Qki enhances cholesterol bio- synthesis by recruiting Srebp2 and Pol II in the promoter regions of cholesterol biosynthesis genes. TīmeklisMechanistically, Qki-5 functions as a co-activator of Srebp2 to control transcription of the genes involved in cholesterol biosynthesis in oligodendrocytes. Consequently, Qki depletion led to substantially reduced concentration of cholesterol in mouse brain, impairing proper myelin assembly. Our study demonstrated that Qki-Srebp2 … TīmeklisMechanistically, we demonstrate that Qki enhances cholesterol biosynthesis by recruiting Srebp2 and Pol II in the promoter regions of cholesterol biosynthesis genes. Supporting its function as a transcription co-activator, we show that Qki directly interacts with single-stranded DNA. roger waters the wall film