Txnrd2是什么
WebDepletion of TXNRD2 to the levels detected in BTZ- or CFZ-treated cells causes oxidative stress, ER stress and death similar to those induced by proteasome inhibitors. Reciprocally, restoration of near-wildtype TXNRD2 amounts in MM cells treated with proteasome inhibitors reduces oxidative stress, ER stress and cell death by ~46%, ~35% and ~50%, … WebHuman mitochondrial thioredoxin reductase (TXNRD2) is a selenocysteine-containing enzyme essential for mitochondrial oxygen radical scavenging. Cardiac-specific deletion …
Txnrd2是什么
Did you know?
WebTXNRD2-201 ENSP00000334451 ENST00000334363: E7EWK1 [Direct mapping] Thioredoxin reductase 2, mitochondrial . Show all. MEMSAT3 predicted membrane proteins … WebJan 11, 2016 · Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. To identify new susceptibility loci, we performed meta-analysis on genome-wide association study (GWAS) results from ...
WebJul 21, 2015 · Background: Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal and associated with abnormal heart development, while constitutive, heart-specific Txnrd2 inactivation leads to dilated cardiomyopathy and perinatal death. The significance of Txnrd2 in aging cardiomyocytes, however, has not yet been examined. WebJul 21, 2015 · Transgenic Mice. Mice carrying loxP‐flanked Txnrd2 alleles (Txnrd2 flfl) were mated to heterozygous Txnrd2 +/− mice carrying a cardiomyocyte‐specific MerCreMer transgene. 14 Generation and genotyping of loxP‐flanked, heterozygous, and heart‐specific knockout (KO) Txnrd2 mice were described previously. 12, 15. Tamoxifen was …
WebAug 7, 2024 · Thioredoxin reductases ( EC 1.6.4.5 ), such as TXNRD2, are selenocysteine (sec)-containing flavoenzymes that maintain thioredoxins, small proteins that catalyze … WebMonoclonal Antibody for studying TXNRD2. Cited in 9 publications. Validated for Western Blotting. Highly specific and rigorously validated in-house, TRXR2/TXNRD2 (3F2-E12-F10) …
WebJul 21, 2015 · It seems that both thioredoxin 2 and Txnrd2 are essential for endogenous cardioprotection in a similar way. 20 Thioredoxin 2 cardiac knockout mice share many …
Web1.2 Thioredoxin Reductase 1. The TrxR1 (also named TXNRD1) enzyme is mainly cytosolic. However, it can also be found in the nucleus, in form of the splice variant TXNRD1_v2, … black lined leather glovesWebApr 1, 2024 · Genetic testing for patient and son revealed a shared VUS in the thioredoxin reductase 2 gene [TXNRD2 Exon 12c.1054C > A(pPro352Thr)]. Thioredoxin reductases (TXNRD) are selenocysteine-containing enzymes encoded by a nuclear gene and are essential for various cell functions, including DNA synthesis, decrease oxidative stress … black lined graph paperWeb丁香通，丁香园旗下专业的生物医药商业信息平台，拥有试剂抗体、仪器耗材、医疗设备、辅料原料药等各类产品供求信息近300万条，致力为医药企业和生物医药相关行业人士建立 … black lined notebook paperWeb1.2 Thioredoxin Reductase 1. The TrxR1 (also named TXNRD1) enzyme is mainly cytosolic. However, it can also be found in the nucleus, in form of the splice variant TXNRD1_v2, where it can modulate the activities of several transcription factors including estrogen receptors (Arnér, 2009; Damdimopoulos, Miranda-Vizuete, Treuter, Gustafsson ... gantt chart microsoft visioWebJul 21, 2015 · Background: Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal and associated with abnormal heart development, while … gantt chart meaning definitionWebMar 5, 2024 · Clinical resource with information about TXNRD2, Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing … gantt chart microsoft office 365WebResults: A stop gain mutation, p.Y447X in TXNRD2, encoding the mitochondrial selenoprotein thioredoxin reductase 2 (TXNRD2) was identified and segregated with … gantt chart microsoft powerpoint